The decidual natural killer cells play a crucial role in providing immune tolerance during pregnancy. Many of their dysfunctions lead to a number of often fatal pathological conditions such as recurrent miscarriages in preeclampsia. Decidual naturacular cells behave differently at the cellular and molecular level in different stages of pregnancy. By increasing our understanding of the matter, a better clinical approach and these pathological conditions will be established and the outcomes of the medical management will be fortunately improved. Future therapeutic remedies could be based on findings from the interactions of cells like the ones presented.
From our experience to tell you the truth and how much scientific literature we studied, so far at least for the last 15 to 20 years, we don’t know the reason. Why do the NK cells go crazy to this woman? We’ve seen women that they don’t smoke, they do a healthy diet, healthy lifestyle – they’re a little bit stressed, maybe stress can cause them to elevate but actually we don’t have a specific scientific answer: why this NK cells, the three markets as I mentioned before, why they go crazy and they get elevated or the functionality increases to these women they want to get pregnant.
Actually, someone would say, we need the immune system naturally to be high enough but for the reproductive medicine we want to suppress it to be in the normal levels. Especially for reproductive medicine after they have their own babies then they can increase their NK levels as much as they can because they support their natural immune status by this way and avoid for them to get sick from flu, from viruses and bacteria and even cancer cells that they circulate to our matrix.
