Diana Obidniak, MD
Fertility Specialist, Head of ART of Birth Clinic, ART of Birth Clinic
Category:
Embryo Implantation, Embryo Transfer, Failed IVF Cycles, Miscarriages and RPL, Success Rates
Implantation is the process of a delicate interaction between an embryo and the endometrium. It is something which needs to happen in order for a pregnancy to develop. Whilst having a high-quality embryo is absolutely key to a successful implantation, it is important that patients understand it’s not the only factor.During a natural menstrual cycle, a woman’s endometrium changes daily in preparation for receiving a fertilised egg. The body naturally knows how to do this and creates a synchronisation between the newly formed embryo and the uterine lining. This is known as the window of implantation and during this time the endometrium is at its maximum receptivity. In IVF, any fertilised eggs are cultivated in a laboratory and developed in vitro (outside of the body), without connection to the endometrium into which it will, hopefully, implant. Helping an embryo to implant is an imperative part of the IVF procedure and a very important topic to discuss. Despite the advances in technology and reproductive knowledge, it is a process that fertility specialists still find challenging. The quality of the embryo is crucial to a successful outcome. With the use of PGS (pre-implantation genetic screening) and time lapse incubators, embryologists now have greater information which helps them to select only healthy, euploid (chromosomally equal) embryos for transfer. In situations where aneuploid (abnormal) embryos are transferred, the endometrium observes any functional and morphological alterations and, in most cases, doesn’t allow the embryo to implant; it acts as a natural defence and a biosensor of embryonic quality.
When patients are using donated oocytes (eggs), it is typically expected that only good calibre embryos will be transferred. If an IVF cycle does unfortunately fail following donor egg IVF, it is likely to be another determinant which is to blame.
Dr Obidniak also recognises that regenerative medicines, such as PRP (platelet-rich plasma) treatments are currently being used to create natural defences within the body.Human blood contains platelets which, in turn, contain hundreds of proteins that are important for healing; PRP therapy can potentially improve the function of the body’s immunity against any fertility related immunological conditions. However as yet, not all additional treatments are fully medically approved, although studies and research are continuously being conducted to help medical scientists improve their knowledge and further understand how to help heathy embryos implant. Dr Obidniak advises that a full medical history is necessary before doctors can even begin to treat women suffering from repeated IVF failure. Medical teams must remember that each patient is unique, their situations are all different and clinics should always create fully individualised treatment protocols for every woman. Recurrent implantation failure is distressing however, treatment options are available to increase the likelihood of implantation and improve the possibility of an embryo developing into a healthy pregnancy and live birth.
Disclaimer:
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Contact details: The European Fertility Society C.I.C., 2 Lambseth Street, Eye, England, IP23 7AGNecessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
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