Should I take supplements? And my partner? In that case, what supplements would you recommend? You have to know, there are millions of supplements out in the market, and it can be very confusing and very tricky to know which ones you should be taking. All of them claim to be like a fantastic solution for your fertility problems. In general terms, most of the data that we have both for men and women say that there is no clear evidence about supplements being something that we should be taking to improve our chances of having a positive outcome, besides the folic acid. We have to make sure that you take it to avoid an increased risk of having neural tube defects. I think that it’s also important to check that you don’t have any deficiency in any specific vitamin. If that’s the case, I think that it should be covered f.e. vitamin D deficiency is something very prevalent because, even though I’m Spanish, and it’s usually very sunny here, I spend most of my days working, so I’m deficient in vitamin D as well, so we won’t get that vitamin from the sun which is the main way to transform the vitamin actively. We should look if we have any specific deficiency, besides the folic acid or any other vitamin deficiency you might have, there is no evidence about the rest of the supplements. About antioxidants for male — Cochrane review indeed said that in patients who have alterations in the sperm in motility and the morphology or the concentration taking antioxidants might be helpful and in some cases might even help to increase the likelihood of having a baby. The problem is that if you ask me, which supplement increases that likelihood of having a baby — we don’t know because most of the studies have been done with combinations of different antioxidants. So we don’t know what is the exact formula. What I can tell you is that most of them have very similar products in it. So the main ones which for example for a male would be using zinc, selenium, vitamin E, vitamin C, and all those are going to be in most of the preparations. Patients, who already done one or two IVF cycles that did not go well and their age is a problem as well, and they found themselves in that situation of maybe doing their last IVF IVF, or possibly they’re moving towards egg donation, when they come for the consultation, they ask what supplements I should be taking. Should I take CoQ10 or melatonin, what is the evidence on taking those? CoQ10 is an antioxidant that was mainly used for cardiac disease, and it showed very good results for cardiac disease and all things related. Coq10 is an antioxidant, so I don’t think that is going to do any harm at all if you take it, but the evidence that we have about the impact it can have on egg quality is very small. There are not so many studies on this that have been published. Only a small number of patients were included in them, and the results are not that conclusive. So what I would say is, it could be helpful, but we don’t have enough evidence to support giving that supplement to all patients. If you can afford it and you want to take it when you’re about to do the last cycle of IVF, or when you are concerned about the egg quality, you can take it. And always, if you take it, it’s better to take it in the form of ubiquinol as you can absorb it better. With melatonin, the situation is pretty much the same, in terms of evidence. Melatonin is one of the hormones that we produce naturally, and it helps us sleep well. There have been some studies issued as well on it and that it can be something which can help with egg quality, but it’s not that clear. I can say the same, if you can afford it and want to take it — you can do it. But keep in mind, the evidence doesn’t say, it should be recommended generally.