In comparison to the medications given by pills, which are still existing intravenous, either intralipids or immunoglobulins are acting immediately. That means as soon as this medication is getting into the blood. The NK cells and the immune system, in general, work differently, so it takes out from the central organ all the NK cells so just mechanism of action and all these NK cells they are going into the periphery to fight with the structure with the molecules which came together with these medications.
We are getting the central organs, which include the uterus, being free from the high levels of the intestines. It is how the mechanism works. It’s valid for 21 to 28 days, it’s very individual, and we need to consider each patient individually, and the treatment should be individualized in terms of prescribing the dosage the frequency of the immunoglobulins. It’s easier to predict in patients who’ve been treated with any kind of immunological treatment before that treatment cycle, however, it’s as easy for those who’ve been unsuccessful. It’s hard to say, but some patients are losing their pregnancies just because we haven’t repeated the IVIG in this particular period.
It happens because, for example, these medications are not used in some countries, and if patients visited Ukraine for the treatment and they’ve got their injections, it would be okay. However, they fly back home, and there is no possibility to repeat it after the positive pregnancy is achieved, even if the heartbeat is confirmed, we need to repeat it, but if there is no opportunity, the result could be different. They will come for the next pregnancy, or we will think about how to get the medications in their country or where to go, so it’s still very temporary action for the immune system by receiving the immunological treatment, and it needs to be checked, and we need to remember that.