First, I would like to comment just shortly about the most common reasons for implantation failure, and it’s in 70-80 % of cases a failure of the embryo. Implantation failure describes the relationship between an embryo and uterine environment, and the clinic should establish a kind of dialogue between both, and the first input always goes out from the embryo. So metabolically, the genetically competent embryo can start this conversation, and then the uterus, and the endometrium usually, only reacts. It is known that about 500 molecular signals are exchanged during the first phase of implantation, but this also means, that 20-30 % of cases of implantation failure we can find the reason in the uterine environment. What does this mean for egg donation patients specifically? So egg donation patients are – from the point of view of the embryo quality – better shaped than normal IVF patients, that have to handle the decreasing quality of their eggs, the increasing age, the increased aneuploidy and genetic imbalance of their embryos, so the critical part for implantation is the embryo quality. So this is how we also learned over the past years and decades about the uterine factors that as mentioned provides 20-30 % of the implantation failures but are very easy to study in an egg donation population. If we can count with 80% of the egg quality already given, we have much more resources to detect small differences in a lot of factors that influence the uterine environment. Just, to mention a couple of them, we will discuss more in detail during the next questions. The first thing for an embryo is to implant. This is a critical time, between getting nutrients from the media where they grew up during the IVF treatment, – even in nature, it’s the same -to get implanted means to get blood flow which means being able to pass this critic time between transfer and implantation. And to assure how to provide themselves with enough blood flow that will bring nutrients later, that will allow to make the placenta and to establish the switch organ, and that will assure the further growth and the supply of nutrients. So this is why blood flow is very important, and we will see in implantation failure cases that usually, the blood flow is diminished. This can happen f. e. if there is a chronic infection like endometritis. If there is a disease like adenomyosis which means there is a chronic inflammation around the subendometrium. Also, in cases of congenital anatomic failures like myomas that interfere in the blood supply of the endometrium. So there could be, let’s say anatomical reasons, but most of the cases are a little bit more depending on hormones, genetics and immunology. We have to understand that fetus and embryo is a foreign body for the mother that has to implant this embryo and nature have foreseen that. There is a special condition during pregnancy that is called immune tolerance where all the machinery fights against intruders, fights against the possible foreign bodies and fights against genetic instances that are different. This immune tolerance means that in the endometrium there is a special condition that allows a foreign body to be accepted and to be implanted, and this is a very suitable and very sensible balance that easily can get these distortions. If the embryo can start this dialogue with the endometrium, the most critical thing that the endometrium has to do is to manage the immunology, manage the hormonal inputs that will allow the embryo to implant, only to a certain time. After 24- 36 hours, this window of implantation gets closed, and then the chance for successful implantation disappears, and in the end, it’s an immunological issue. So in egg donation what we find, is that usually patients with higher age than in normal IVF, and all these qualities f.e. immunology, autoimmune diseases will increase with age, therefore, patients undergoing egg donation are more prone to have such kind of problems. In terms of the displacement of the window of implantation – so the hormonal response of the endometrium – there is some slower activity in women beyond a certain age. I would say around 40 or older where the synchronization between embryo and endometrium may fail, and these are all conditions despite the anatomy which is congenital and applies for everybody that has it but all other threes a higher incidence with increasing age. This is why it is so critical for egg donation patients to be aware of those risk and to adapt protocols to that special situation.