Maria Arqué, MD
Specialist in obstetrics and gynecology & reproductive medicine, Founder and Medical Director at Gynnergy
Category:
Donor Eggs, Embryo Implantation, Failed IVF Cycles, Miscarriages and RPL
There are three main recognised causes behind unsuccessful donor egg IVF treatments; the embryo, the endometrium and the blood flow and immunology.
Male factor can also affect embryonic health and various testing, including karyotypes and DNA fragmentation, is always recommended.Whilst a good calibre embryo is key for a positive outcome following any IVF treatment, it is important to understand that it is not the only determinant. In order to implant, a healthy embryo also needs a favourable environment. Anatomical uterine factors such as fibroids, polyps, adhesions or other malformations can affect embryo implantation. Clinics should fully screen the recipient’s uterine cavity, to look for any endometrial issues, in advance of any donor egg IVF treatments. If an egg is fertilised and implants during a natural cycle, the newly pregnant body enters the luteal phase. During this stage of pregnancy, the corpus luteum naturally produces the correct amount of progesterone required to support pregnancy development. All of which needs to be closely replicated when undergoing assisted conception; transferring the embryo during the correct window of endometrial receptivity is imperative. Clinics should ensure the recipient’s endometrium and hormonal levels are ready to accept the embryo. Progesterone is usually prescribed, and recipients are monitored in advance of the transfer.
Another cause, which can affect implantation is the thickness of the endometrium wall.
Blood flow and immunology might currently be considered as controversial subjects but are believed to have a negative impact on implantation. Conditions such as thrombophilia (an abnormal tendency to develop blood clots) and / or Natural Killer Cells may affect the recipient.Dr Arque explains that although it is known a healthy immune system and good blood flow to the endometrium are essential for implantation, the current medical understanding surrounding these issues remains incomplete. She advises that immune testing and empirical treatments must be approached with caution until further data is gathered, and more definitive conclusions can be made.
Donor egg IVF treatment can fail, even with a top-grade embryo. For a pregnancy to become established implantation must also happen, and for that a healthy endometrium and immune system is necessary.It is important to remember that every person is unique, it is, therefore, the duty of clinics to provide a tailormade service for each individual. The window of endometrial receptivity is not necessarily the same for all patients and preparing the hormones and uterine cavity won’t always be achieved by using standardised protocols. A thoroughly personalised embryo transfer, completely in sync with the recipient’s body, is what clinics should strive for and is what will ultimately help achieve the only outcome wanted from donor egg IVF. Read more about IVF with donor eggs failed cycles:
Disclaimer:
Informations published on myIVFanswers.com are provided for informational purposes only; they are not intended to treat, diagnose or prevent any disease including infertility treatment. Services provided by myIVFanswers.com are not intended to replace a one-on-one relationship with a qualified health care professional and are not intended as medical advice. MyIVFanswers.com recommend discussing IVF treatment options with an infertility specialist.
Contact details: The European Fertility Society C.I.C., 2 Lambseth Street, Eye, England, IP23 7AGNecessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Cookie | Duration | Description |
---|---|---|
_ga | 2 years | This cookie is installed by Google Analytics. The cookie is used to calculate visitor, session, campaign data and keep track of site usage for the site's analytics report. The cookies store information anonymously and assign a randomly generated number to identify unique visitors. |
_gat_UA-38575237-21 | 1 minute | No description |
_gid | 1 day | This cookie is installed by Google Analytics. The cookie is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. The data collected including the number visitors, the source where they have come from, and the pages visted in an anonymous form. |
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
Cookie | Duration | Description |
---|---|---|
_gat_FSQM52 | 1 minute | No description |
cf_ob_info | No description | |
cf_use_ob | No description |