- What is egg freezing recommended for?
- What are the legal/medical/social indications and altruistic reasons?
- What do reproductive-age women who do egg freezing think about the process as a means to preserve their fertility?
- Limits and risks of oocyte cryopreservation
- What are the clinical pregnancy rates per warmed oocyte compared to fresh oocytes?
- What is the cost in the UK?
Is egg freezing for me?
When should you freeze your eggs? What is the cost? Watch the recording of the live webinar with Prof. Luciano Nardo, MD MRCOG, the Clinical Director at Reproductive Health Group, to find out more about egg freezing.
Questions and Answers from the event
How many eggs do you recommend to freeze? Is one cycle of egg freezing enough?
There are no recommendations, there’s no evidence of how many eggs you should be freezing, however, the data published in the literature and in relation to the number of oocytes to be used to achieve a successful pregnancy of IVF suggests that perhaps between 12 and 15 eggs is the optimum number. Obviously, that refers to fresh eggs. If you take into account the vitrification and depending on age, probably between 80 – 90% of eggs will survive the freezing and thawing process. Then, in my opinion, a safe number of eggs to be cryopreserved will be probably around 20. If that number can be achieved through 1 cycle, that’s great, but sometimes, I would say in most cases to avoid the risk of OHSS perhaps that number of mature oocytes is achieved in a couple of cycles.
I’m 38 and due to trying to freeze the eggs this year. Realistically, am I wasting my time?
It is not a matter of wasting time or wasting money, it is a matter of you being informed. I would suggest that first of all, you assess your ovarian reserve by having an AMH and perhaps also an ultrasound scan for antral follicle count to see how in relation to your chronological age, how your biological age is, how your ovaries work. You need to be aware that because of your age, you may need to have if you’re embarking on egg freezing, perhaps more than one cycle and realistically more than the 20 eggs that I was referring to earlier on. Some of these eggs that may be mature at the time of freezing may not survive, may not fertilize. Some may not become healthy embryos, so it is not a matter of wasting time or wasting money, it’s a matter of knowing what the chances of success are and knowing that age per se is a limitation, but not a contraindication.
We need to use donor eggs and are torn between doing a fresh cycle and using an egg bank. Frozen eggs require ICSI, but fresh eggs can use normal IVF is that correct? Is using the IVF a more natural selection process for an embryo to develop?
That is correct. If you use frozen eggs, you need to have ICSI because the membrane of the egg is thick and will not allow the sperm to swim inside easily, so ICSI is required to fertilize frozen and thawed eggs. IVF seems to be a more natural form of fertilization because the best sperm will be swimming inside the egg. However, there is no evidence, and there is no study to demonstrate in a comparison between ICSI with frozen eggs and IVF with fresh eggs both coming from donor eggs that one is superior to the other one. I showed you the data from one of the best cryobanks in Europe, showing actually, that there’s no difference whatsoever in the pregnancy outcome using fresh or frozen eggs.
Is there an equivalent to egg washing process as with sperm washing when it comes to egg retrieval and freezing process?
I’m not entirely sure about what you mean by egg washing, we’re not washing the eggs. After egg collection, the eggs are put in a plastic dish and embryologists in the lab will be assessing the eggs a few hours after the collection, to help preserve only those eggs that are mature. So, eggs are put in culture media, and for a couple of hours after the collection, they are cryopreserved only if mature.
Some programs offer ‘Guarantee Embryos’ from buying vitrified oocytes which have been PGD-24 tested as well as underwent the comprehensive 600 panels of genetic carrier diseases. Would the success rate be the same as the statistics you mentioned in your presentation or better if they are transferred to a very good surrogate who already had her own healthy child?
I think so, yes. The statistics are the same provided that there are good quality embryos, and the embryos come from a healthy donor that have been genetically tested. Then the chance of success will be exactly the same. The surrogate obviously plays a role, and I think some investigations will have to be carried out on the surrogate. Especially, if things have changed since she has had a healthy child, but I would not suggest that because you’re intending to use frozen eggs, you will have a significantly lower chance of success.
What is your opinion regarding healthy and good PGD24 tested embryos to be transferred to a healthy surrogate? Should the surrogate still do an amniocentesis to make sure the baby is growing well without problems? What ‘might’ be potential problems later in the pregnancy with good PGD 24 embryos?
No, that’s not needed. If the embryos have been genetically tested, irrespective of coming from a donor or not, from fresh or frozen eggs, there is no need to do an invasive test that increases the risk of miscarriage, such as the amniocentesis.
You said the cut off age of freezing eggs is 35. Can you freeze eggs if you are a 41-year-old woman with good AMH?
It is possible, age is not a contraindication, it’s just a limitation. You can freeze your eggs if you’re over the age of 35. If you have a good AMH that is a bonus, but we know that a good AMH does not guarantee normal, healthy eggs. You need to be aware that chronologically, you will be determining the fate of the eggs by simply preserving eggs at the time in your life when you have already passed the best fertility potential. So, yes you can, it’s good that you got a good AMH level, but you will have a lower chance of success as I presented in my slides compared to somebody who’s younger than the age of 35.
I’m 43, could you please explain again the live birth rates with <35-year-old eggs?
The live birth rate and the pregnancy outcomes overall are twice as high in someone who is under 35 with somebody who is over 35. The chances in your age group, so over the age of 35 are probably 1 in 4 of what would be in someone at the age of 35. It is probably going to be around 10% compared to being around 30% in someone under the age of 35. It is still possible, but it’s not something I would recommend, so freezing eggs at your age but if you have a good ovarian reserve, and probably you will need several cycles of stimulation, egg collection and egg freezing to collect cryopreserve 20 to 25 oocytes.
How many eggs would you ideally like to freeze for an older woman?
I think the number of eggs to freeze for an older woman will be higher than freezing the number of eggs in younger women. Simply, because we know that not all eggs will survive, and not all eggs will fertilize, and not all eggs will form healthy normal embryos. So just, to give you an indication if you were to freeze 20 eggs for somebody’s under the age of 35 probably you’re looking at increasing twice the number of eggs in someone over the age of 35. The problem is whether actually, you’re going to get that number of eggs and whether that number of eggs is realistically based on how many cycles of stimulation and collection the woman will require.
How many embryos would you expect from 10 frozen eggs if someone froze their eggs at 33?
We’re talking about blastocyst, so day-5 or day-6 embryos, and I would probably expect at least 3 good quality blastocysts.
What are the risks of egg freezing when a woman has AIDS or other infectious diseases?
The risk of cross-contamination, those are the risks, but there are no other risks per se. This is the same as treating women that are viral positive in a heterosexual relationship or homosexual relationship and fertilizing the eggs fresh, so the risks are exactly the same. In the UK, the treatment can only be undertaken in some units with a specific viral positive lab, but again it’s not a contraindication to egg freezing.
Can you increase your chances of success with lifestyle, diet changes?
Absolutely, anything that will help your general well-being will increase your chance of success, but I want to be absolutely clear in this context that adapting to a healthy lifestyle, changing diet, nutrition, exercise, normal body mass index, non-smoking, no alcohol – they’re not going to be changing the biological clock. I’m afraid adapting the best possible lifestyle at the age of 32- 33 may improve things, but 10 years later it’s not going to rewind the biological clock, so the chances of success are going to be pretty much the same. Probably there’s going to be a slight benefit in pregnancy, but I would not be saying that healthy women who are over the age of 35 have a significantly better chance of success, as compared to women that maybe not as healthy.
Can you do egg freezing cycles straight after one or do you have to wait?
Yes, you can do it, and we do it in our clinic. We have had patients having 2 up to 3 egg freezing cycles back to back and, in fact, there is some evidence that suggests especially in women with the reduced ovaria reserve that ongoing stimulation may have a cumulative positive effect.
At the age of 43, not having the best AMH, is it irresponsible trying still to have my own child with IVF?
It is not irresponsible at all. It’s a choice, but you have to be prepared to accept a higher chance of negative outcome because compared to somebody who is younger. You can have your own child with IVF, we have had many women at your age with low AMH with normal AMH for their age, having a successful pregnancy outcome. I would not say it is irresponsible, it’s just knowing the limitations and having realistic expectations.
Are there side effects of egg freezing cycles back to back? Like hyperstimulation (OHSS)?
No, there’s no risk of hyperstimulation provided that the ovarian stimulation cycle is monitored carefully and the dose of medications is selected and tailored to the underlying factors such as age and ovarian reserve, so there is no risk of hyperstimulation.
Are there any limitations for egg freezing in cases of woman that suffer from mental disorders or for example, Turner syndrome?
There are no limitations. In mental disorders it is it’s just a matter in receiving adequate support and implications counselling, so making sure that there is a good understanding of the process and more importantly that the patient has good support at home, and with regard to Turner syndrome is making sure that there is a satisfactory ovarian reserve and knowing that there might not be any eggs suitable for harvesting or there may not be eggs that are suitable for fertilization. It’s not a limitation itself, it’s just an underlying and genetic disorder that impacts significantly on the fertility and the productive potential of the woman.
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