It depends on the experience of the doctor as well to make sure that we go at the right time, and that’s one of the challenges of our job to make sure that we don’t go to collect the eggs when it’s too early or when it’s too late. Sometimes, this is a bit of a learning curve, each woman is different, each patient is different, and the difference is not just between the patients, but it’s also between the same patients in different cycles, so some patients react to a drug in a certain way, and then the same patients react to a different drug or the same drug differently. There is a minimum number of days that it would be advisable for stimulation and to go too early with the stimulation. It’s not just a problem with the eggs, it’s also a problem with the endometrium. Don’t forget that those eggs produce hormones, and the hormones will prepare the lining of the endometrium for the pregnancy, so there must be enough exposure to the endometrium to the estrogens, otherwise, we end up having an embryo, which goes into the endometrial cavity, to an environment, which is not synchronized with the age of the embryo, and that is one of the reasons why embryos don’t implant if the endometrium is not well prepared. There have to be at least 10 days of stimulation to allow the good maturation of the lining, and then the decision is usually taken together, it’s not just the follicular size, but it’s also the thickness of the lining and the appearance of the lining. Once we get those eggs out, we expect some of them to be immature, so not all the eggs are mature maybe, 20-10% of the eggs can be immature, very rarely they are over mature, but sometimes if they are over matured possibly, it’s because we left it too late to collect, and in some protocols, this can happen because they don’t get released. After all, you’re taking the drugs to stop you from releasing the eggs, nevertheless, they pass that stage, and they’re just not good enough to be fertilized.