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How are X-linked dominant gene mutations passed down through the family?

2 fertility expert(s) answered this question

How are X linked dominant traits inherited?

What is interesting in X-linked inheritance is that fathers do not pass X-linked traits to their sons. They can only pass X chromosomes to their daughters and Y chromosomes to their sons.

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Answer from the fertility expert:
Maria José Mendiola, Gynaecologist in Reproductive Medicine & Reproductive Genetics, Clínica Monterrico

We have two scenarios, first if the mother is affected by a condition caused by the x like dominant gene mutation, for example when the mother has a condition caused by a x dominant gene mutation, there are different possibilities for what the child can receive from the parents or a couple. This means that in every pregnancy there is 50% one in two chance that both sons and daughters will inherit the x dominant gene mutation from the mother and half the condition the gene product is not made in the right way by the cells and one in two we have a 50% chance that children (could be both sons and daughters) will inherit the working copy of the gene from her and they will not have that condition. On the other way, we have another scenario if the father is affected by a condition caused by an x-linked dominant gene mutation, in this case, the father will pass on the x-linked dominant gene mutation on the chromosome to all his daughters and pass on his Y chromosome to all his songs. So, the unaffected mother will only give working copies of the gene for her to the children and for such a couple, there are different possibilities – the child can receive new chromosome discoveries from the parents. We have one chance that known after zones no none of their sons can inherit the x-linked dominant gene mutations is the son only inherits the Y chromosome from the father, they will inherit the working gene copy from their mother, none of their sons will have the conditions but all of their daughters will inherit the working gene copy from their mother and the x dominant gene variant or mutation from their father so, in this case all the daughters will therefore have the condition.

Answer from the fertility expert:
Douglas Lester, Co-Founder & Chief Scientific Officer, Fertility Genomics

X-linked dominant mutations are passed from mother to son or daughter or from the father to his daughter. The father can’t pass it on to his son because he passes on his Y chromosome, not his X, to his son.

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